View source for 4jfo

{{STRUCTURE_4jfo|  PDB=4jfo  |  SCENE=  }} 
===A2 HLA complex with E1A heteroclitic variant of Melanoma peptide===
{{ABSTRACT_PUBMED_23698002}}

==Disease==
[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>   Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>  

==Function==
[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. 

==About this Structure==
[[4jfo]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JFO OCA]. 

==Reference==
<ref group="xtra">PMID:023698002</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Baker, B M.]]
[[Category: Cole, D K.]]
[[Category: Madura, F.]]
[[Category: Rizkallah, P J.]]
[[Category: Sewell, A K.]]
[[Category: High affinity]]
[[Category: Hla]]
[[Category: Immune system]]
[[Category: Immunoglobulin]]
[[Category: Melanoma]]
[[Category: Tcr]]