View source for 4ijo

{{STRUCTURE_4ijo|  PDB=4ijo  |  SCENE=  }} 
===Unraveling hidden allosteric regulatory sites in structurally homologues metalloproteases===
{{ABSTRACT_PUBMED_23583775}}

==Function==
[[http://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN]] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. 

==About this Structure==
[[4ijo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJO OCA]. 

==Reference==
<ref group="xtra">PMID:017096442</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Macrophage elastase]]
[[Category: Arad-Yellin, R.]]
[[Category: Berezovsky, I N.]]
[[Category: Calderone, V.]]
[[Category: Fragai, M.]]
[[Category: Grossman, M.]]
[[Category: Luchinat, C.]]
[[Category: Melikian, M.]]
[[Category: Mitternacht, S.]]
[[Category: Sagi, I.]]
[[Category: Toccafondi, M.]]
[[Category: Udi, Y.]]
[[Category: Amphiphol]]
[[Category: Degradation of the extracellular matrix protein]]
[[Category: Extracellular]]
[[Category: Hydrolase]]
[[Category: Matrix metalloproteinase]]
[[Category: Regulatory site]]