View source for 3jr3

{{STRUCTURE_3jr3|  PDB=3jr3  |  SCENE=  }} 
===Sir2 bound to acetylated peptide===
{{ABSTRACT_PUBMED_019801667}}

==Function==
[[http://www.uniprot.org/uniprot/NPD_THEMA NPD_THEMA]] NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Has also depropionylation activity in vitro. Also able to ADP-ribosylate peptide substrates with Arg or Lys in the +2 position. The role of this function in vivo is not clear.<ref>PMID:17684016</ref><ref>PMID:16905097</ref><ref>PMID:19801667</ref> 

==About this Structure==
[[3jr3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JR3 OCA]. 

==Reference==
<ref group="xtra">PMID:019801667</ref><references group="xtra"/><references/>
[[Category: Thermotoga maritima]]
[[Category: Hawse, W F.]]
[[Category: Wolberger, C.]]
[[Category: Deacetylation]]
[[Category: Hydrolase]]
[[Category: Metal-binding]]
[[Category: Nad]]
[[Category: Nad+]]
[[Category: Ribosylation]]
[[Category: Sir2]]