View source for 2xe7

{{STRUCTURE_2xe7|  PDB=2xe7  |  SCENE=  }} 
===THE COMPLETE REACTION CYCLE OF HUMAN PHOSPHOGLYCERATE KINASE: THE OPEN TERNARY COMPLEX WITH 3PG AND ADP===
{{ABSTRACT_PUBMED_21349853}}

==Disease==
[[http://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN]] Defects in PGK1 are the cause of phosphoglycerate kinase 1 deficiency (PGK1D) [MIM:[http://omim.org/entry/300653 300653]]. It is a condition with a highly variable clinical phenotype that includes hemolytic anemia, rhabdomyolysis, myopathy and neurologic involvement. Patients can express one or more of these manifestations.<ref>PMID:8673469</ref><ref>PMID:8043870</ref><ref>PMID:8615693</ref><ref>PMID:9744480</ref><ref>PMID:2001457</ref><ref>PMID:1586722</ref><ref>PMID:1547346</ref><ref>PMID:6941312</ref><ref>PMID:6933565</ref> 

==Function==
[[http://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN]] In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). 

==About this Structure==
[[2xe7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XE7 OCA]. 

==See Also==
*[[Phosphoglycerate Kinase|Phosphoglycerate Kinase]]

==Reference==
<ref group="xtra">PMID:021349853</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Phosphoglycerate kinase]]
[[Category: Baxter, N J.]]
[[Category: Blackburn, G M.]]
[[Category: Bowler, M W.]]
[[Category: Cliff, M J.]]
[[Category: Merli, A.]]
[[Category: Vas, M.]]
[[Category: Waltho, J P.]]
[[Category: Domain motion]]
[[Category: Glycolysis]]
[[Category: Hereditary hemolytic anemia]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Phosphoryl transfer]]
[[Category: Transferase]]
[[Category: Transition state analogue]]