View source for 1ryu

{{STRUCTURE_1ryu|  PDB=1ryu  |  SCENE=  }} 
===Solution Structure of the SWI1 ARID===
{{ABSTRACT_PUBMED_14722072}}

==Disease==
[[http://www.uniprot.org/uniprot/ARI1A_HUMAN ARI1A_HUMAN]] Defects in ARID1A are the cause of mental retardation autosomal dominant type 14 (MRD14) [MIM:[http://omim.org/entry/614607 614607]]. A disease characterized by multiple congenital anomalies and mental retardation. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRD14 patients manifest developmental delay, abnormal corpus callosum, absent/hypoplastic fifth finger/toenails, sparse scalp hair, long eyelashes, and a coarse facial appearance with wide mouth, thick lips, and abnormal ears.<ref>PMID:22426308</ref> 

==Function==
[[http://www.uniprot.org/uniprot/ARI1A_HUMAN ARI1A_HUMAN]] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).<ref>PMID:12837248</ref> 

==About this Structure==
[[1ryu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RYU OCA]. 

==Reference==
<ref group="xtra">PMID:014722072</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Chen, Y.]]
[[Category: Isern, N.]]
[[Category: Kim, S.]]
[[Category: Upchurch, S.]]
[[Category: Zhang, Z.]]
[[Category: Arid]]
[[Category: Dna binding protein]]
[[Category: Protein-dna interaction]]
[[Category: Structural genomic]]
[[Category: Swi1]]