View source for 2vuf

{{STRUCTURE_2vuf|  PDB=2vuf  |  SCENE=  }} 
===HUMAN SERUM ALBUMIN COMPLEXED WITH FUSIDIC ACID===
{{ABSTRACT_PUBMED_18602119}}

==Disease==
[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref><ref>PMID:7852505</ref><ref>PMID:9329347</ref><ref>PMID:9589637</ref> 

==Function==
[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref> 

==About this Structure==
[[2vuf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VUF OCA]. 

==See Also==
*[[Albumin|Albumin]]

==Reference==
<ref group="xtra">PMID:018602119</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Curry, S.]]
[[Category: Ghuman, J.]]
[[Category: Zunszain, P A.]]
[[Category: Albumin]]
[[Category: Carrier protein]]
[[Category: Cleavage on pair of basic residue]]
[[Category: Disease mutation]]
[[Category: Drug-binding]]
[[Category: Fusidic acid]]
[[Category: Glycation]]
[[Category: Glycoprotein]]
[[Category: Lipid-binding]]
[[Category: Metal-binding]]
[[Category: Secreted]]
[[Category: Transport protein]]