View source for 1mf7

{{STRUCTURE_1mf7|  PDB=1mf7  |  SCENE=  }} 
===INTEGRIN ALPHA M I DOMAIN===
{{ABSTRACT_PUBMED_12611591}}

==Disease==
[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[http://omim.org/entry/609939 609939]]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. 

==Function==
[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. 

==About this Structure==
[[1mf7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MF7 OCA]. 

==See Also==
*[[Integrin|Integrin]]

==Reference==
<ref group="xtra">PMID:012611591</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Liddington, R C.]]
[[Category: McCleverty, C J.]]
[[Category: Cell adhesion]]