View source for 3mrb

{{STRUCTURE_3mrb|  PDB=3mrb  |  SCENE=  }} 
===Crystal Structure of MHC class I HLA-A2 molecule complexed with HCMV pp65-495-503 nonapeptide A7H variant===

==Disease==
[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>  Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref><ref>PMID:1336137</ref><ref>PMID:7554280</ref><ref>PMID:4586824</ref><ref>PMID:8084451</ref><ref>PMID:12119416</ref><ref>PMID:12796775</ref><ref>PMID:16901902</ref><ref>PMID:16491088</ref><ref>PMID:17646174</ref><ref>PMID:18835253</ref><ref>PMID:18395224</ref><ref>PMID:19284997</ref> 

==Function==
[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. 

==About this Structure==
[[3mrb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MRB OCA]. 

==See Also==
*[[Beta-2 microglobulin|Beta-2 microglobulin]]
*[[Major histocompatibility complex|Major histocompatibility complex]]

==Reference==
<references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Bonneville, M.]]
[[Category: Chouquet, A.]]
[[Category: Debeaupuis, E.]]
[[Category: Echasserieau, K.]]
[[Category: Gras, S.]]
[[Category: Housset, D.]]
[[Category: Reiser, J B.]]
[[Category: Saulquin, X.]]
[[Category: Cytomegalovirus]]
[[Category: Hla]]
[[Category: Immune response]]
[[Category: Immune system]]
[[Category: Mhc class i]]
[[Category: Nonapeptide]]
[[Category: Pp65 protein]]
[[Category: Viral peptide]]