View source for 4ahf

{{STRUCTURE_4ahf|  PDB=4ahf  |  SCENE=  }} 
===K17E - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis===
{{ABSTRACT_PUBMED_23047679}}

==Disease==
[[http://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN]] Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:[http://omim.org/entry/611895 611895]]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.<ref>PMID:17886298</ref><ref>PMID:15557516</ref><ref>PMID:16501576</ref><ref>PMID:17900154</ref><ref>PMID:18087731</ref><ref>PMID:17703939</ref> 

==Function==
[[http://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN]] May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.<ref>PMID:1400510</ref><ref>PMID:19354288</ref> 

==About this Structure==
[[4ahf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AHF OCA]. 

==Reference==
<references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Acharya, K R.]]
[[Category: Ferguson, R.]]
[[Category: Pham, T.]]
[[Category: Saha, S.]]
[[Category: Subramanian, V.]]
[[Category: Thiyagarajan, N.]]
[[Category: Al]]
[[Category: Ang]]
[[Category: Hydrolase]]
[[Category: Neovascularisation]]