View source for 1ug3

{{STRUCTURE_1ug3|  PDB=1ug3  |  SCENE=  }} 
===C-terminal portion of human eIF4GI===

==Disease==
[[http://www.uniprot.org/uniprot/IF4G1_HUMAN IF4G1_HUMAN]] Defects in EIF4G1 are the cause of Parkinson disease type 18 (PARK18) [MIM:[http://omim.org/entry/614251 614251]]. An autosomal dominant, late-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.<ref>PMID:21907011</ref> 

==Function==
[[http://www.uniprot.org/uniprot/IF4G1_HUMAN IF4G1_HUMAN]] Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. 

==About this Structure==
[[1ug3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UG3 OCA]. 

==See Also==
*[[C-terminal portion of human eIF4GI|C-terminal portion of human eIF4GI]]
*[[Death Associated Protein 5|Death Associated Protein 5]]
*[[Eukaryotic initiation factor|Eukaryotic initiation factor]]

==Reference==
<ref group="xtra">PMID:016698542</ref><ref group="xtra">PMID:016156639</ref><ref group="xtra">PMID:016698552</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Bellsolell, L.]]
[[Category: Burley, S K.]]
[[Category: Cho-Park, P F.]]
[[Category: Poulin, F.]]
[[Category: Sonenberg, N.]]
[[Category: Eif4g]]
[[Category: Heat repeat]]
[[Category: Translation]]