View source for 1oax

[[Image:1oax.gif|left|200px]]<br />
<applet load="1oax" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1oax, resolution 2.67&Aring;" />
'''FV STRUCTURE OF THE IGE SPE-7 IN COMPLEX WITH ACENAPHTHENEQUINONE'''<br />

==Overview==
A single antibody was shown to adopt different binding-site conformations, and thereby bind unrelated antigens. Analysis by both x-ray, crystallography and pre-steady-state kinetics revealed an equilibrium, between different preexisting isomers, one of which possessed a, promiscuous, low-affinity binding site for aromatic ligands, including the, immunizing hapten. A subsequent induced-fit isomerization led to, high-affinity complexes with a deep and narrow binding site. A protein, antigen identified by repertoire selection made use of an unrelated, antibody isomer with a wide, shallow binding site. Conformational, diversity, whereby one sequence adopts multiple structures and multiple, functions, can increase the effective size of the antibody repertoire but, may also lead to autoimmunity ... [[http://ispc.weizmann.ac.il/pmbin/getpm?12610298 (full description)]]

==About this Structure==
1OAX is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]] with ANQ as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OAX OCA]]. 

==Reference==
Antibody multispecificity mediated by conformational diversity., James LC, Roversi P, Tawfik DS, Science. 2003 Feb 28;299(5611):1362-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12610298 12610298]
[[Category: Protein complex]]
[[Category: Rattus rattus]]
[[Category: James, L.C.]]
[[Category: Roversi, P.]]
[[Category: Tawfik, D.]]
[[Category: ANQ]]
[[Category: allergy]]
[[Category: antibody]]
[[Category: ige]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 15:48:30 2007''