View source for 1o72

[[Image:1o72.gif|left|200px]]<br />
<applet load="1o72" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1o72, resolution 2.41&Aring;" />
'''CRYSTAL STRUCTURE OF THE WATER-SOLUBLE STATE OF THE PORE-FORMING CYTOLYSIN STICHOLYSIN II COMPLEXED WITH PHOSPHORYLCHOLINE'''<br />

==Overview==
Sticholysin II (StnII) is a pore-forming protein (PFP) produced by the sea, anemone Stichodactyla helianthus. We found out that StnII exists in a, monomeric soluble state but forms tetramers in the presence of a lipidic, interface. Both structures have been independently determined at 1.7 A and, 18 A resolution, respectively, by using X-ray crystallography and electron, microscopy of two-dimensional crystals. Besides, the structure of soluble, StnII complexed with phosphocholine, determined at 2.4 A resolution, reveals a phospholipid headgroup binding site, which is located in a, region with an unusually high abundance of aromatic residues. Fitting of, the atomic model into the electron microscopy density envelope suggests, that while the beta sandwich structure of the protein remains ... [[http://ispc.weizmann.ac.il/pmbin/getpm?14604522 (full description)]]

==About this Structure==
1O72 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]] with PC as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1O72 OCA]]. 

==Reference==
Crystal and electron microscopy structures of sticholysin II actinoporin reveal insights into the mechanism of membrane pore formation., Mancheno JM, Martin-Benito J, Martinez-Ripoll M, Gavilanes JG, Hermoso JA, Structure. 2003 Nov;11(11):1319-28. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14604522 14604522]
[[Category: Single protein]]
[[Category: Stichodactyla helianthus]]
[[Category: Gavilanes, J.G.]]
[[Category: Hermoso, J.A.]]
[[Category: Mancheno, J.M.]]
[[Category: Martinez-Ripoll, M.]]
[[Category: PC]]
[[Category: cytolysin]]
[[Category: hemolysis]]
[[Category: membrane interaction]]
[[Category: pore-forming toxin]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 15:45:00 2007''