View source for 2aaq

[[Image:2aaq.gif|left|200px]]<br /><applet load="2aaq" size="350" color="white" frame="true" align="right" spinBox="true" 
caption="2aaq, resolution 2.60&Aring;" />
'''Crystal Structure Analysis of the human Glutahione Reductase, complexed with GoPI'''<br />

==Disease==
Known diseases associated with this structure: Hemolytic anemia due to glutathione reductase deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138300 138300]], Mental retardation, autosomal recessive, 6 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138244 138244]]

==About this Structure==
2AAQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=K:'>K</scene>, <scene name='pdbligand=FAD:'>FAD</scene>, <scene name='pdbligand=AUP:'>AUP</scene>, <scene name='pdbligand=AU:'>AU</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Glutathione-disulfide_reductase Glutathione-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.7 1.8.1.7] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AAQ OCA]. 

==Reference==
Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases., Urig S, Fritz-Wolf K, Reau R, Herold-Mende C, Toth K, Davioud-Charvet E, Becker K, Angew Chem Int Ed Engl. 2006 Mar 13;45(12):1881-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16493712 16493712]
[[Category: Glutathione-disulfide reductase]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Becker, K.]]
[[Category: Davioud-Charvet, E.]]
[[Category: Fritz-Wolf, K.]]
[[Category: Herold-Mende, C.]]
[[Category: Reau, R.]]
[[Category: Toth, K.]]
[[Category: Urig, S.]]
[[Category: AU]]
[[Category: AUP]]
[[Category: CL]]
[[Category: FAD]]
[[Category: GOL]]
[[Category: K]]
[[Category: PO4]]
[[Category: antioxidative system]]
[[Category: disulfide reductase]]
[[Category: glutathione reduction]]
[[Category: gold-coordination]]
[[Category: homodimer]]
[[Category: protein gold complex]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:25:37 2008''