View source for 1xoo

[[Image:1xoo.gif|left|200px]]<br /><applet load="1xoo" size="350" color="white" frame="true" align="right" spinBox="true" 
caption="1xoo" />
'''NMR structure of G1S mutant of influenza hemagglutinin fusion peptide in DPC micelles at pH 5'''<br />

==Overview==
Influenza virus hemagglutinin (HA)-mediated membrane fusion is initiated by a conformational change that releases a V-shaped hydrophobic fusion domain, the fusion peptide, into the lipid bilayer of the target membrane. The most N-terminal residue of this domain, a glycine, is highly conserved and is particularly critical for HA function; G1S and G1V mutant HAs cause hemifusion and abolish fusion, respectively. We have determined the atomic resolution structures of the G1S and G1V mutant fusion domains in membrane environments. G1S forms a V with a disrupted "glycine edge" on its N-terminal arm and G1V adopts a slightly tilted linear helical structure in membranes. Abolishment of the kink in G1V results in reduced hydrophobic penetration of the lipid bilayer and an increased propensity to form beta-structures at the membrane surface. These results underline the functional importance of the kink in the fusion peptide and suggest a structural role for the N-terminal glycine ridge in viral membrane fusion.

==About this Structure==
1XOO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XOO OCA]. 

==Reference==
Membrane structures of the hemifusion-inducing fusion peptide mutant G1S and the fusion-blocking mutant G1V of influenza virus hemagglutinin suggest a mechanism for pore opening in membrane fusion., Li Y, Han X, Lai AL, Bushweller JH, Cafiso DS, Tamm LK, J Virol. 2005 Sep;79(18):12065-76. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16140782 16140782]
[[Category: Protein complex]]
[[Category: Bushweller, J H.]]
[[Category: Cafiso, D S.]]
[[Category: Han, X.]]
[[Category: Lai, A L.]]
[[Category: Li, Y.]]
[[Category: Tamm, L K.]]
[[Category: helix-kink-helix]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:57:00 2008''