View source for 1gt1

[[Image:1gt1.gif|left|200px]]<br />
<applet load="1gt1" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1gt1, resolution 1.71&Aring;" />
'''COMPLEX OF BOVINE ODORANT BINDING PROTEIN WITH AMINOANTHRACENE AND PYRAZINE'''<br />

==Overview==
The structure of bovine odorant-binding protein (bOBP) revealed a striking, feature of a dimer formed by domain swapping [Tegoni, M., Ramoni, R., Bignetti, E., Spinelli, S. &amp; Cambillau, C. (1996) Nat. Struct. Biol.3, 863-867; Bianchet, M.A., Bains, G., Pelosi, P., Pevsner, J., Snyder, S.H., Monaco, H.L. &amp; Amzel, L.M. (1996) Nat. Struct. Biol.3, 934-939] and the, presence of a naturally occuring ligand [Ramoni, R., Vincent, F., Grolli, S., Conti, V., Malosse, C., Boyer, F.D., Nagnan-Le Meillour, P., Spinelli, S., Cambillau, C. &amp; Tegoni, M. (2001) J. Biol. Chem.276, 7150-7155]. These, features led us to investigate the binding of odorant molecules with bOBP, in solution and in the crystal. The behavior of odorant molecules in bOBP, resembles that observed with porcine OBP ... [[http://ispc.weizmann.ac.il/pmbin/getpm?15373829 (full description)]]

==About this Structure==
1GT1 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with PRZ and ANC as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: PRZ. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GT1 OCA]]. 

==Reference==
Crystal structures of bovine odorant-binding protein in complex with odorant molecules., Vincent F, Ramoni R, Spinelli S, Grolli S, Tegoni M, Cambillau C, Eur J Biochem. 2004 Oct;271(19):3832-42. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15373829 15373829]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Cambillau, C.]]
[[Category: Conti, V.]]
[[Category: Grolli, S.]]
[[Category: Ramoni, R.]]
[[Category: Spinelli, S.]]
[[Category: Tegoni, M.]]
[[Category: Vincent, F.]]
[[Category: ANC]]
[[Category: PRZ]]
[[Category: bovine odorant binding protein]]
[[Category: lipocalin]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 15:18:31 2007''