View source for 1gqv

[[Image:1gqv.gif|left|200px]]<br />
<applet load="1gqv" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1gqv, resolution 0.98&Aring;" />
'''ATOMIC RESOLUTION (0.98A) STRUCTURE OF EOSINOPHIL-DERIVED NEUROTOXIN'''<br />

==Overview==
Human eosinophil-derived neurotoxin (EDN) is a small, basic protein that, belongs to the ribonuclease A superfamily. EDN displays antiviral activity, and causes the neurotoxic Gordon phenomenon when injected into rabbits., Although EDN and ribonuclease A have appreciable structural similarity and, a conserved catalytic triad, their peripheral substrate-binding sites are, not conserved. The crystal structure of recombinant EDN (rEDN) has been, determined at 0.98 A resolution from data collected at a low temperature, (100 K). We have refined the crystallographic model of the structure using, anisotropic displacement parameters to a conventional R-factor of 0.116., This represents the highest resolution structure of rEDN determined to, date and is only the second ribonuclease structure to be ... [[http://ispc.weizmann.ac.il/pmbin/getpm?11876642 (full description)]]

==About this Structure==
1GQV is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ACT as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GQV OCA]]. 

==Reference==
Atomic resolution (0.98 A) structure of eosinophil-derived neurotoxin., Swaminathan GJ, Holloway DE, Veluraja K, Acharya KR, Biochemistry. 2002 Mar 12;41(10):3341-52. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11876642 11876642]
[[Category: Homo sapiens]]
[[Category: Pancreatic ribonuclease]]
[[Category: Single protein]]
[[Category: Acharya, K.R.]]
[[Category: Holloway, D.E.]]
[[Category: Swaminathan, G.J.]]
[[Category: Veluraja, K.]]
[[Category: ACT]]
[[Category: ribonuclease]]
[[Category: rnase us]]
[[Category: rnase-2]]

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