View source for 1nt0

[[Image:1nt0.gif|left|200px]]<br /><applet load="1nt0" size="350" color="white" frame="true" align="right" spinBox="true" 
caption="1nt0, resolution 2.70&Aring;" />
'''Crystal structure of the CUB1-EGF-CUB2 region of MASP2'''<br />

==Overview==
Serum mannose-binding proteins (MBPs) are C-type lectins that recognize cell surface carbohydrate structures on pathogens, and trigger killing of these targets by activating the complement pathway. MBPs circulate as a complex with MBP-associated serine proteases (MASPs), which become activated upon engagement of a target cell surface. The minimal functional unit for complement activation is a MASP homodimer bound to two MBP trimeric subunits. MASPs have a modular structure consisting of an N-terminal CUB domain, a Ca(2+)-binding EGF-like domain, a second CUB domain, two complement control protein modules and a C-terminal serine protease domain. The CUB1-EGF-CUB2 region mediates homodimerization and binding to MBP. The crystal structure of the MASP-2 CUB1-EGF-CUB2 dimer reveals an elongated structure with a prominent concave surface that is proposed to be the MBP-binding site. A model of the full six-domain structure and its interaction with MBPs suggests mechanisms by which binding to a target cell transmits conformational changes from MBP to MASP that allow activation of its protease activity.

==About this Structure==
1NT0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=EDO:'>EDO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NT0 OCA]. 

==Reference==
Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2., Feinberg H, Uitdehaag JC, Davies JM, Wallis R, Drickamer K, Weis WI, EMBO J. 2003 May 15;22(10):2348-59. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12743029 12743029]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Davies, J M.]]
[[Category: Drickamer, K.]]
[[Category: Feinberg, H.]]
[[Category: Uitdehaag, J C.M.]]
[[Category: Wallis, R.]]
[[Category: Weis, W I.]]
[[Category: CA]]
[[Category: EDO]]
[[Category: NAG]]
[[Category: cub domain]]
[[Category: egf like domain.]]
[[Category: mannose-binding protein]]
[[Category: masp]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:09:38 2008''