View source for 1nnp

[[Image:1nnp.gif|left|200px]]<br /><applet load="1nnp" size="350" color="white" frame="true" align="right" spinBox="true" 
caption="1nnp, resolution 1.90&Aring;" />
'''X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.9 A resolution. Crystallization without zinc ions.'''<br />

==Overview==
Two X-ray structures of the GluR2 ligand-binding core in complex with (S)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid ((S)-ATPA) have been determined with and without Zn(2+) ions. (S)-ATPA induces a domain closure of ca. 21 degrees compared to the apo form. The tert-butyl moiety of (S)-ATPA is buried in a partially hydrophobic pocket and forces the ligand into the glutamate-like binding mode. The structures provide new insight into the molecular basis of agonist selectivity between AMPA and kainate receptors.

==About this Structure==
1NNP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=CE2:'>CE2</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NNP OCA]. 

==Reference==
Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity., Lunn ML, Hogner A, Stensbol TB, Gouaux E, Egebjerg J, Kastrup JS, J Med Chem. 2003 Feb 27;46(5):872-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12593667 12593667]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Egebjerg, J.]]
[[Category: Gouaux, E.]]
[[Category: Hogner, A.]]
[[Category: Kastrup, J S.]]
[[Category: Lunn, M L.]]
[[Category: Stensbol, T B.]]
[[Category: CE2]]
[[Category: SO4]]
[[Category: agonist complex.]]
[[Category: ionotropic glutamate receptor glur2]]
[[Category: ligand-binding core]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:08:01 2008''