View source for 1lbe

[[Image:1lbe.gif|left|200px]]<br /><applet load="1lbe" size="350" color="white" frame="true" align="right" spinBox="true" 
caption="1lbe, resolution 2.4&Aring;" />
'''APLYSIA ADP RIBOSYL CYCLASE'''<br />

==Overview==
ADP ribosyl cyclase synthesizes the novel secondary messenger cyclic ADP ribose (cADPR) utilizing NAD as a substrate. The enzyme shares extensive sequence similarity with two lymphocyte antigens, CD38 and BST-1, which hydrolyse as well as synthesize cADPR. The crystal structure provides a model for these cell surface enzymes. Cyclase contains two spatially separated pockets composed of sequence conserved residues, suggesting that the cyclization reaction may entail use of distinct sites. The enzyme dimer encloses a cavity which may entrap the intermediate, ADP ribose.

==About this Structure==
1LBE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Active as [http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LBE OCA]. 

==Reference==
Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38., Prasad GS, McRee DE, Stura EA, Levitt DG, Lee HC, Stout CD, Nat Struct Biol. 1996 Nov;3(11):957-64. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8901875 8901875]
[[Category: Aplysia californica]]
[[Category: NAD(+) nucleosidase]]
[[Category: Single protein]]
[[Category: Lee, H C.]]
[[Category: Levitt, D G.]]
[[Category: Mcree, D E.]]
[[Category: Prasad, G S.]]
[[Category: Stout, C D.]]
[[Category: Stura, E A.]]
[[Category: hydrolase]]
[[Category: nad(+) nucleosidase]]
[[Category: nadase]]

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