View source for 1jnp

[[Image:1jnp.jpg|left|200px]]<br /><applet load="1jnp" size="350" color="white" frame="true" align="right" spinBox="true" 
caption="1jnp, resolution 2.50&Aring;" />
'''Crystal Structure of Murine Tcl1 at 2.5 Resolution'''<br />

==Overview==
Tcl1 and Mtcp1, members of the Tcl1 family, are implicated in T-cell prolymphocytic leukemia. The crystal structure of a dimer of murine Tcl1 has been determined at 2.5 A resolution with an R factor of 0.225. Murine Tcl1, human Tcl1 and Mtcp1 share very similar subunit structures, with RMS differences of 0.6 and 1.4 A for C(alpha) atoms, respectively, while the sequences share 50 and 36% identity, respectively. These structures fold into an eight-stranded beta-barrel of unique topology and high internal symmetry of 1.1-1.3 A for the two halves of human and murine Tcl1 and 1.7 A for Mtcp1, despite the low 12-13% sequence identity. The molecular surfaces of all three structures showed a common planar region which is likely to be involved in protein-protein interactions.

==About this Structure==
1JNP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNP OCA]. 

==Reference==
Structure of murine Tcl1 at 2.5 A resolution and implications for the TCL oncogene family., Petock JM, Torshin IY, Wang YF, Du Bois GC, Croce CM, Harrison RW, Weber IT, Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1545-51. Epub 2001, Oct 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11679718 11679718]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Croce, C M.]]
[[Category: DuBois, G C.]]
[[Category: Harrison, R W.]]
[[Category: Petock, J M.]]
[[Category: Torshin, I Y.]]
[[Category: Wang, Y F.]]
[[Category: Weber, I T.]]
[[Category: beta barrel]]
[[Category: dimer]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:24:37 2008''