View source for 1ihv

[[Image:1ihv.gif|left|200px]]<br /><applet load="1ihv" size="350" color="white" frame="true" align="right" spinBox="true" 
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'''SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, MINIMIZED AVERAGE STRUCTURE'''<br />

==Overview==
The solution structure of the DNA binding domain of HIV-1 integrase (residues 220-270) has been determined by multidimensional NMR spectroscopy. The protein is a dimer in solution, and each subunit is composed of a five-stranded beta-barrel with a topology very similar to that of the SH3 domain. The dimer is formed by a stacked beta-interface comprising strands 2, 3, and 4, with the two triple-stranded antiparallel beta-sheets, one from each subunit, oriented antiparallel to each other. One surface of the dimer, bounded by the loop between strands beta 1 and beta 2, forms a saddle-shaped groove with dimensions of approximately 24 x 23 x 12 A in cross section. Lys264, which has been shown from mutational data to be involved in DNA binding, protrudes from this surface, implicating the saddle-shaped groove as the potential DNA binding site.

==About this Structure==
1IHV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IHV OCA]. 

==Reference==
Solution structure of the DNA binding domain of HIV-1 integrase., Lodi PJ, Ernst JA, Kuszewski J, Hickman AB, Engelman A, Craigie R, Clore GM, Gronenborn AM, Biochemistry. 1995 Aug 8;34(31):9826-33. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7632683 7632683]
[[Category: Human immunodeficiency virus]]
[[Category: Single protein]]
[[Category: Clore, G M.]]
[[Category: Ernst, J A.]]
[[Category: Gronenborn, A M.]]
[[Category: Lodi, P J.]]
[[Category: aids]]
[[Category: dna-binding protein]]
[[Category: polyprotein]]

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