View source for 1hla

[[Image:1hla.gif|left|200px]]<br /><applet load="1hla" size="350" color="white" frame="true" align="right" spinBox="true" 
caption="1hla, resolution 3.5&Aring;" />
'''STRUCTURE OF THE HUMAN CLASS I HISTOCOMPATIBILITY ANTIGEN, HLA-A2'''<br />

==Overview==
The class I histocompatibility antigen from human cell membranes has two structural motifs: the membrane-proximal end of the glycoprotein contains two domains with immunoglobulin-folds that are paired in a novel manner, and the region distal from the membrane is a platform of eight antiparallel beta-strands topped by alpha-helices. A large groove between the alpha-helices provides a binding site for processed foreign antigens. An unknown 'antigen' is found in this site in crystals of purified HLA-A2.

==Disease==
Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142800 142800]], Ankylosing spondylitis, susceptibility to, 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142800 142800]], Hypoproteinemia, hypercatabolic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109700 109700]], Stevens-Johnson syndrome, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142800 142800]]

==About this Structure==
1HLA is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HLA OCA]. 

==Reference==
Structure of the human class I histocompatibility antigen, HLA-A2., Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC, Nature. 1987 Oct 8-14;329(6139):506-12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=3309677 3309677]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Bennett, W S.]]
[[Category: Bjorkman, P J.]]
[[Category: Samraoui, B.]]
[[Category: Saper, M A.]]
[[Category: Strominger, J L.]]
[[Category: Wiley, D C.]]
[[Category: histocompatibility antigen]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:02:27 2008''