View source for 2j7n

[[Image:2j7n.gif|left|200px]]<br />
<applet load="2j7n" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="2j7n, resolution 2.30&Aring;" />
'''STRUCTURE OF THE RNAI POLYMERASE FROM NEUROSPORA CRASSA'''<br />

==Overview==
RNA silencing refers to a group of RNA-induced gene-silencing mechanisms, that developed early in the eukaryotic lineage, probably for defence, against pathogens and regulation of gene expression. In plants, protozoa, fungi, and nematodes, but apparently not insects and vertebrates, it, involves a cell-encoded RNA-dependent RNA polymerase (cRdRP) that produces, double-stranded RNA triggers from aberrant single-stranded RNA. We report, the 2.3-A resolution crystal structure of QDE-1, a cRdRP from Neurospora, crassa, and find that it forms a relatively compact dimeric molecule, each, subunit of which comprises several domains with, at its core, a catalytic, apparatus and protein fold strikingly similar to the catalytic core of the, DNA-dependent RNA polymerases responsible for ... [[http://ispc.weizmann.ac.il/pmbin/getpm?17147473 (full description)]]

==About this Structure==
2J7N is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]] with MG and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J7N OCA]]. 

==Reference==
The structure of an RNAi polymerase links RNA silencing and transcription., Salgado PS, Koivunen MR, Makeyev EV, Bamford DH, Stuart DI, Grimes JM, PLoS Biol. 2006 Dec;4(12):e434. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17147473 17147473]
[[Category: Neurospora crassa]]
[[Category: Single protein]]
[[Category: Bamford, D.H.]]
[[Category: Grimes, J.M.]]
[[Category: Koivunen, M.R.L.]]
[[Category: Makeyev, E.V.]]
[[Category: Salgado, P.S.]]
[[Category: Stuart, D.I.]]
[[Category: GOL]]
[[Category: MG]]
[[Category: hydrolase]]
[[Category: hypothetical protein]]
[[Category: rna dependent rna polymerase]]
[[Category: rna-directed rna polymerase]]
[[Category: rnai response]]

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