View source for 1faw

[[Image:1faw.jpg|left|200px]]<br /><applet load="1faw" size="350" color="white" frame="true" align="right" spinBox="true" 
caption="1faw, resolution 3.09&Aring;" />
'''GRAYLAG GOOSE HEMOGLOBIN (OXY FORM)'''<br />

==Overview==
The greylag goose (Anser anser), which lives on lowlands and cannot tolerate hypoxic conditions, presents a striking contrast to its close relative the bar-headed goose (A. indicus), which lives at high altitude and possesses high-altitude hypoxia adaptation. There are only four amino-acid residue differences at alpha18, alpha63, alpha119 and beta125 between the haemoglobins of the two species. The crystal structure of greylag goose oxy haemoglobin was determined at 3.09 A resolution. Its quaternary structure is slightly different from that of the bar-headed goose oxy haemoglobin, with a rotation of 2.8 degrees in relative orientation of the two dimers. Of the four mutations, those at alpha119 and beta125 produce contact changes in the alpha(1)beta(1) interface and may be responsible for the differences in intrinsic oxygen affinity between the two species; those at alpha18 and alpha63 may be responsible for the differences in quaternary structure between the two species.

==About this Structure==
1FAW is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Anser_anser Anser anser] with <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=OXY:'>OXY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FAW OCA]. 

==Reference==
The structure of greylag goose oxy haemoglobin: the roles of four mutations compared with bar-headed goose haemoglobin., Liang YH, Liu XZ, Liu SH, Lu GY, Acta Crystallogr D Biol Crystallogr. 2001 Dec;57(Pt 12):1850-6. Epub 2001, Nov 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11717498 11717498]
[[Category: Anser anser]]
[[Category: Protein complex]]
[[Category: Liang, Y H.]]
[[Category: Liu, S H.]]
[[Category: Liu, X Z.]]
[[Category: Lu, G Y.]]
[[Category: HEM]]
[[Category: OXY]]
[[Category: erythrocyte]]
[[Category: heme]]
[[Category: oxygen transport]]
[[Category: respiratory protein]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:36:45 2008''