View source for 1hg4

[[Image:1hg4.gif|left|200px]]<br />
<applet load="1hg4" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1hg4, resolution 2.4&Aring;" />
'''ULTRASPIRACLE LIGAND BINDING DOMAIN FROM DROSOPHILA MELANOGASTER'''<br />

==Overview==
Ultraspiracle (USP) is the invertebrate homologue of the mammalian, retinoid X receptor (RXR). RXR plays a uniquely important role in, differentiation, development, and homeostasis through its ability to serve, as a heterodimeric partner to many other nuclear receptors. RXR is able to, influence the activity of its partner receptors through the action of the, ligand 9-cis retinoic acid. In contrast to RXR, USP has no known, high-affinity ligand and is thought to be a silent component in the, heterodimeric complex with partner receptors such as the ecdysone, receptor. Here we report the 2.4-A crystal structure of the USP, ligand-binding domain. The structure shows that a conserved sequence motif, found in dipteran and lepidopteran USPs, but not in mammalian RXRs, serves, to lock USP in an ... [[http://ispc.weizmann.ac.il/pmbin/getpm?11171988 (full description)]]

==About this Structure==
1HG4 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]] with LPP as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HG4 OCA]]. 

==Reference==
The structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformation., Clayton GM, Peak-Chew SY, Evans RM, Schwabe JW, Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1549-54. Epub 2001 Feb 6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11171988 11171988]
[[Category: Drosophila melanogaster]]
[[Category: Single protein]]
[[Category: Clayton, G.M.]]
[[Category: Schwabe, J.W.R.]]
[[Category: LPP]]
[[Category: ligand binding]]
[[Category: nuclear hormone receptor]]
[[Category: transcription factor]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 16:08:17 2007''