View source for 2cea

[[Image:2cea.gif|left|200px]]<br />
<applet load="2cea" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="2cea, resolution 2.75&Aring;" />
'''WILDTYPE'''<br />

==Overview==
The ATP-dependent integral membrane protease FtsH is universally conserved, in bacteria. Orthologs exist in chloroplasts and mitochondria, where in, humans the loss of a close FtsH-homolog causes a form of spastic, paraplegia. FtsH plays a crucial role in quality control by degrading, unneeded or damaged membrane proteins, but it also targets soluble, signaling factors like sigma(32) and lambda-CII. We report here the, crystal structure of a soluble FtsH construct that is functional in, caseinolytic and ATPase assays. The molecular architecture of this, hexameric molecule consists of two rings where the protease domains, possess an all-helical fold and form a flat hexagon that is covered by a, toroid built by the AAA domains. The active site of the protease, classifies FtsH as an ... [[http://ispc.weizmann.ac.il/pmbin/getpm?16484367 (full description)]]

==About this Structure==
2CEA is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]] with ZN, MG and ADP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CEA OCA]]. 

==Reference==
The molecular architecture of the metalloprotease FtsH., Bieniossek C, Schalch T, Bumann M, Meister M, Meier R, Baumann U, Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3066-71. Epub 2006 Feb 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16484367 16484367]
[[Category: Single protein]]
[[Category: Thermotoga maritima]]
[[Category: Baumann, U.]]
[[Category: Bieniossek, C.]]
[[Category: ADP]]
[[Category: MG]]
[[Category: ZN]]
[[Category: cell division]]
[[Category: cell division protein]]
[[Category: ftsh]]
[[Category: metalloprotease]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:38:56 2007''