View source for 1gve

[[Image:1gve.gif|left|200px]]<br />
<applet load="1gve" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1gve, resolution 1.38&Aring;" />
'''AFLATOXIN ALDEHYDE REDUCTASE (AKR7A1) FROM RAT LIVER'''<br />

==Overview==
The structure of the rat liver aflatoxin dialdehyde reductase (AKR7A1) has, been solved to 1.38-A resolution. Although it shares a similar, alpha/beta-barrel structure with other members of the aldo-keto reductase, superfamily, AKR7A1 is the first dimeric member to be crystallized. The, crystal structure also reveals details of the ternary complex as one, subunit of the dimer contains NADP(+) and the inhibitor citrate. Although, the underlying catalytic mechanism appears similar to other aldo-keto, reductases, the substrate-binding pocket contains several charged amino, acids (Arg-231 and Arg-327) that distinguish it from previously, characterized aldo-keto reductases with respect to size and charge. These, differences account for the substrate specificity for 4-carbon, acid-aldehydes ... [[http://ispc.weizmann.ac.il/pmbin/getpm?11839745 (full description)]]

==About this Structure==
1GVE is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with NAP, CIT and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GVE OCA]]. 

==Reference==
The crystal structure of rat liver AKR7A1. A dimeric member of the aldo-keto reductase superfamily., Kozma E, Brown E, Ellis EM, Lapthorn AJ, J Biol Chem. 2002 May 3;277(18):16285-93. Epub 2002 Feb 11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11839745 11839745]
[[Category: Protein complex]]
[[Category: Rattus norvegicus]]
[[Category: Brown, E.]]
[[Category: Ellis, E.M.]]
[[Category: Kozma, E.]]
[[Category: Lapthorn, A.J.]]
[[Category: CIT]]
[[Category: GOL]]
[[Category: NAP]]
[[Category: aflatoxin b1]]
[[Category: akr7 family]]
[[Category: aldo-keto reductase]]
[[Category: succinic semialdehyde oxidoreductase]]

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