View source for 1xed

[[Image:1xed.jpg|left|200px]]<br /><applet load="1xed" size="350" color="white" frame="true" align="right" spinBox="true" 
caption="1xed, resolution 1.90&Aring;" />
'''Crystal Structure of a Ligand-Binding Domain of the Human Polymeric Ig Receptor, pIgR'''<br />

==Overview==
The polymeric immunoglobulin receptor (pIgR) is a type I transmembrane, protein that delivers dimeric IgA (dIgA) and pentameric IgM to mucosal, secretions. Here, we report the 1.9 A resolution X-ray crystal structure, of the N-terminal domain of human pIgR, which binds dIgA in the absence of, other pIgR domains with an equilibrium dissociation constant of 300 nM., The structure of pIgR domain 1 reveals a folding topology similar to, immunoglobulin variable domains, but with differences in the counterparts, of the complementarity determining regions (CDRs), including a helical, turn in CDR1 and a CDR3 loop that points away from the other CDRs. The, unusual CDR3 loop position prevents dimerization analogous to the pairing, of antibody variable heavy and variable light domains. The pIgR domain 1, structure allows interpretation of previous mutagenesis results and, structure-based comparisons between pIgR and other IgA receptors.

==Disease==
Known disease associated with this structure: IgA nephropathy, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=173880 173880]]

==About this Structure==
1XED is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XED OCA]. 

==Reference==
Crystal structure of a polymeric immunoglobulin binding fragment of the human polymeric immunoglobulin receptor., Hamburger AE, West AP Jr, Bjorkman PJ, Structure. 2004 Nov;12(11):1925-35. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15530357 15530357]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Bjorkman, P.J.]]
[[Category: Hamburger, A.E.]]
[[Category: Jr., A.P.West.]]
[[Category: MG]]
[[Category: ig-like fold]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:09:04 2008''