View source for 2bx2

[[Image:2bx2.gif|left|200px]]<br />
<applet load="2bx2" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="2bx2, resolution 2.85&Aring;" />
'''CATALYTIC DOMAIN OF E. COLI RNASE E'''<br />

==Overview==
The coordinated regulation of gene expression is required for homeostasis, growth and development in all organisms. Such coordination may be partly, achieved at the level of messenger RNA stability, in which the targeted, destruction of subsets of transcripts generates the potential for, cross-regulating metabolic pathways. In Escherichia coli, the balance and, composition of the transcript population is affected by RNase E, an, essential endoribonuclease that not only turns over RNA but also processes, certain key RNA precursors. RNase E cleaves RNA internally, but its, catalytic power is determined by the 5' terminus of the substrate, even if, this lies at a distance from the cutting site. Here we report crystal, structures of the catalytic domain of RNase E as trapped allosteric, ... [[http://ispc.weizmann.ac.il/pmbin/getpm?16237448 (full description)]]

==About this Structure==
2BX2 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with MG and ZN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BX2 OCA]]. 

==Reference==
Structure of Escherichia coli RNase E catalytic domain and implications for RNA turnover., Callaghan AJ, Marcaida MJ, Stead JA, McDowall KJ, Scott WG, Luisi BF, Nature. 2005 Oct 20;437(7062):1187-91. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16237448 16237448]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Callaghan, A.J.]]
[[Category: Luisi, B.F.]]
[[Category: Marcaida, M.J.]]
[[Category: Scott, W.G.]]
[[Category: MG]]
[[Category: ZN]]
[[Category: endonuclease]]
[[Category: hydrolase]]
[[Category: nuclease]]
[[Category: rna processing]]
[[Category: rna turnover]]
[[Category: rna-binding]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:16:12 2007''