View source for 1qlf

[[Image:1qlf.jpg|left|200px]]<br /><applet load="1qlf" size="350" color="white" frame="true" align="right" spinBox="true" 
caption="1qlf, resolution 2.65&Aring;" />
'''MHC CLASS I H-2DB COMPLEXED WITH GLYCOPEPTIDE K3G'''<br />

==Overview==
Two synthetic O-GlcNAc-bearing peptides that elicit H-2Db-restricted, glycopeptide-specific cytotoxic T cells (CTL) have been shown to display, nonreciprocal patterns of cross-reactivity. Here, we present the crystal, structures of the H-2Db glycopeptide complexes to 2.85 A resolution or, better. In both cases, the glycan is solvent exposed and available for, direct recognition by the T cell receptor (TCR). We have modeled the, complex formed between the MHC-glycopeptide complexes and their respective, TCRs, showing that a single saccharide residue can be accommodated in the, standard TCR-MHC geometry. The models also reveal a possible molecular, basis for the observed cross-reactivity patterns of the CTL clones, which, appear to be influenced by the length of the CDR3 loop and the nature of, the immunizing ligand.

==Disease==
Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109700 109700]]

==About this Structure==
1QLF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Sendai_virus Sendai virus] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QLF OCA]. 

==Reference==
Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity., Glithero A, Tormo J, Haurum JS, Arsequell G, Valencia G, Edwards J, Springer S, Townsend A, Pao YL, Wormald M, Dwek RA, Jones EY, Elliott T, Immunity. 1999 Jan;10(1):63-74. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10023771 10023771]
[[Category: Homo sapiens]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Sendai virus]]
[[Category: Jones, E.Y.]]
[[Category: Tormo, J.]]
[[Category: GOL]]
[[Category: NAG]]
[[Category: SO4]]
[[Category: antigen]]
[[Category: glycopeptide]]
[[Category: histocompatibility]]
[[Category: immunology]]
[[Category: mhc]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:45:03 2008''