View source for 1i27

[[Image:1i27.gif|left|200px]]<br /><applet load="1i27" size="350" color="white" frame="true" align="right" spinBox="true" 
caption="1i27, resolution 1.02&Aring;" />
'''CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF THE RAP74 SUBUNIT OF HUMAN TRANSCRIPTION FACTOR IIF (TFIIF)'''<br />

==Overview==
The x-ray structure of a C-terminal fragment of the RAP74 subunit of human, transcription factor (TF) IIF has been determined at 1.02-A resolution., The alpha/beta structure is strikingly similar to the globular domain of, linker histone H5 and the DNA-binding domain of hepatocyte nuclear factor, 3gamma (HNF-3gamma), making it a winged-helix protein. The surface, electrostatic properties of this compact domain differ significantly from, those of bona fide winged-helix transcription factors (HNF-3gamma and, RFX1) and from the winged-helix domains found within the RAP30 subunit of, TFIIF and the beta subunit of TFIIE. RAP74 has been shown to interact with, the TFIIF-associated C-terminal domain phosphatase FCP1, and a putative, phosphatase binding site has been identified within the RAP74 winged-helix, domain.

==About this Structure==
1I27 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I27 OCA]. 

==Reference==
Crystal structure of the C-terminal domain of the RAP74 subunit of human transcription factor IIF., Kamada K, De Angelis J, Roeder RG, Burley SK, Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3115-20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11248041 11248041]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Angelis, J.De.]]
[[Category: Burley, S.K.]]
[[Category: Kamada, K.]]
[[Category: Roeder, R.G.]]
[[Category: ZN]]
[[Category: general transcription factor]]
[[Category: rap30]]
[[Category: rap74]]
[[Category: rna polymerase ii]]
[[Category: tfiif]]
[[Category: winged-helix domain]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:59:07 2008''