View source for 1ga3

[[Image:1ga3.jpg|left|200px]]<br /><applet load="1ga3" size="350" color="white" frame="true" align="right" spinBox="true" 
caption="1ga3" />
'''NMR STRUCTURE OF INTERLEUKIN-13'''<br />

==Overview==
The complex and interrelated function of the interleukin cytokines relies, on a range of pro-inflammatory and anti-inflammatory immune responses, mediated by an array of receptors, and there is considerable, cross-reactivity for related cytokines. Recent findings continue to, elucidate the expression patterns of interleukin receptors associated with, a range of diseases, including cancer. We report here the first, experimentally determined high-resolution structure of human, interleukin-13 (IL-13). The experimental structure is significantly, different from an earlier homology model, which could have led to improper, estimation of receptor interaction surfaces and design of mutational, experiments. Similarities between the presented IL-13 structure and the, homologous interleukin-4 (IL-4) are discussed. Additionally, mutation data, for IL-4 and IL-13 are analyzed and combined with a detailed structural, analysis of the IL-4/IL4Ralpha interface that leads us to postulate, interactions at the IL-13/receptor interface. The structural comparison is, used to interpret the different affinities for various receptors and, establishes the basis for further mutational experiments and antagonist, design.

==Disease==
Known diseases associated with this structure: Allergic rhinitis, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147683 147683]], Asthma, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147683 147683]]

==About this Structure==
1GA3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GA3 OCA]. 

==Reference==
Solution structure of interleukin-13 and insights into receptor engagement., Eisenmesser EZ, Horita DA, Altieri AS, Byrd RA, J Mol Biol. 2001 Jun 29;310(1):231-41. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11419949 11419949]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Altieri, A.S.]]
[[Category: Byrd, R.A.]]
[[Category: Eisenmesser, E.Z.]]
[[Category: Horita, D.A.]]
[[Category: cytokine]]
[[Category: il-13]]
[[Category: il13]]
[[Category: interleukin-13]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:51:53 2008''