View source for 1oar

[[Image:1oar.jpg|left|200px]]<br /><applet load="1oar" size="350" color="white" frame="true" align="right" spinBox="true" 
caption="1oar, resolution 2.23&Aring;" />
'''FV IGE SPE-7 IN COMPLEX WITH ALIZARIN RED'''<br />

==Overview==
A single antibody was shown to adopt different binding-site conformations, and thereby bind unrelated antigens. Analysis by both x-ray, crystallography and pre-steady-state kinetics revealed an equilibrium, between different preexisting isomers, one of which possessed a, promiscuous, low-affinity binding site for aromatic ligands, including the, immunizing hapten. A subsequent induced-fit isomerization led to, high-affinity complexes with a deep and narrow binding site. A protein, antigen identified by repertoire selection made use of an unrelated, antibody isomer with a wide, shallow binding site. Conformational, diversity, whereby one sequence adopts multiple structures and multiple, functions, can increase the effective size of the antibody repertoire but, may also lead to autoimmunity and allergy.

==About this Structure==
1OAR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus] with <scene name='pdbligand=CAC:'>CAC</scene>, <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=DMS:'>DMS</scene>, <scene name='pdbligand=EDO:'>EDO</scene> and <scene name='pdbligand=AZN:'>AZN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Cl+Binding+Site+For+Chain+N'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAR OCA]. 

==Reference==
Antibody multispecificity mediated by conformational diversity., James LC, Roversi P, Tawfik DS, Science. 2003 Feb 28;299(5611):1362-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12610298 12610298]
[[Category: Rattus rattus]]
[[Category: Single protein]]
[[Category: James, L.C.]]
[[Category: Roversi, P.]]
[[Category: Tawfik, D.]]
[[Category: AZN]]
[[Category: CAC]]
[[Category: CL]]
[[Category: DMS]]
[[Category: EDO]]
[[Category: NA]]
[[Category: allergy]]
[[Category: antibody]]
[[Category: conformational diversity]]
[[Category: ige]]
[[Category: multispecificity]]

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