View source for 2ojt

[[Image:2ojt.jpg|left|200px]]<br /><applet load="2ojt" size="350" color="white" frame="true" align="right" spinBox="true" 
caption="2ojt, resolution 1.95&Aring;" />
'''Structure and mechanism of kainate receptor modulation by anions'''<br />

==Overview==
L-glutamate, the major excitatory neurotransmitter in the human brain, activates a family of ligand-gated ion channels, the major subtypes of, which are named AMPA, kainate, and NMDA receptors. In common with many, signal transduction proteins, glutamate receptors are modulated by ions, and small molecules, including Ca(2+), Mg(2+), Zn(2+), protons, polyamines, and steroids. Strikingly, the activation of kainate receptors, by glutamate requires the presence of both Na(+) and Cl(-) in the, extracellular solution, and in the absence of these ions, receptor, activity is abolished. Here, we identify the site and mechanism of action, of anions. Surprisingly, we find that Cl(-) ions are essential structural, components of kainate receptors. Cl(-) ions bind in a cavity formed at the, interface between subunits in a dimer pair. In the absence of Cl(-), dimer, stability is reduced, the rate of desensitization increases, and the, fraction of receptors competent for activation by glutamate drops, precipitously.

==About this Structure==
2OJT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=BR:'>BR</scene>, <scene name='pdbligand=1PE:'>1PE</scene> and <scene name='pdbligand=UBA:'>UBA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJT OCA]. 

==Reference==
Structure and mechanism of kainate receptor modulation by anions., Plested AJ, Mayer ML, Neuron. 2007 Mar 15;53(6):829-41. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17359918 17359918]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Mayer, M.L.]]
[[Category: 1PE]]
[[Category: BR]]
[[Category: UBA]]
[[Category: membrane protein]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 21:12:08 2008''