View source for 3b9w

[[Image:3b9w.gif|left|200px]]<br /><applet load="3b9w" size="350" color="white" frame="true" align="right" spinBox="true" 
caption="3b9w, resolution 1.30&Aring;" />
'''The 1.3 A resolution structure of Nitrosomonas europaea Rh50 and mechanistic implications for NH3 transport by Rhesus family proteins'''<br />

==Overview==
The Rhesus (Rh) proteins are a family of integral membrane proteins found, throughout the animal kingdom that also occur in a number of lower, eukaryotes. The significance of Rh proteins derives from their presence in, the human red blood cell membrane, where they constitute the second most, important group of antigens used in transfusion medicine after the ABO, group. Rh proteins are related to the ammonium transport (Amt) protein, family and there is considerable evidence that, like Amt proteins, they, function as ammonia channels. We have now solved the structure of a rare, bacterial homologue (from Nitrosomonas europaea) of human Rh50 proteins at, a resolution of 1.3 A. The protein is a trimer, and analysis of its, subunit interface strongly argues that all Rh proteins are likely to be, homotrimers and that the human erythrocyte proteins RhAG and RhCE/D are, unlikely to form heterooligomers as previously proposed. When compared, with structures of bacterial Amt proteins, NeRh50 shows several, distinctive features of the substrate conduction pathway that support the, concept that Rh proteins have much lower ammonium affinities than Amt, proteins and might potentially function bidirectionally.

==About this Structure==
3B9W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Nitrosomonas_europaea Nitrosomonas europaea] with <scene name='pdbligand=BOG:'>BOG</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B9W OCA]. 

==Reference==
The 1.3-A resolution structure of Nitrosomonas europaea Rh50 and mechanistic implications for NH3 transport by Rhesus family proteins., Lupo D, Li XD, Durand A, Tomizaki T, Cherif-Zahar B, Matassi G, Merrick M, Winkler FK, Proc Natl Acad Sci U S A. 2007 Nov 21;. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18032606 18032606]
[[Category: Nitrosomonas europaea]]
[[Category: Single protein]]
[[Category: Lupo, D.]]
[[Category: Winkler, F.K.]]
[[Category: BOG]]
[[Category: GOL]]
[[Category: ammonia transport]]
[[Category: membrane protein]]
[[Category: rhesus protein]]
[[Category: transport protein]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 11:50:41 2008''