View source for 2rjs

[[Image:2rjs.jpg|left|200px]]<br /><applet load="2rjs" size="350" color="white" frame="true" align="right" spinBox="true" 
caption="2rjs, resolution 2.400&Aring;" />
'''SgTAM bound to substrate mimic'''<br />

==Overview==
The synthesis and evaluation of two classes of inhibitors for SgTAM, a, 4-methylideneimidazole-5-one (MIO) containing tyrosine aminomutase, are, described. A mechanism-based strategy was used to design analogs that, mimic the substrate or product of the reaction and form covalent, interactions with the enzyme through the MIO prosthetic group. The analogs, were characterized by measuring inhibition constants and X-ray, crystallographic structural analysis of the co-complexes bound to the, aminomutase, SgTAM.

==About this Structure==
2RJS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_globisporus Streptomyces globisporus] with <scene name='pdbligand=296:'>296</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Tyrosine_2,3-aminomutase Tyrosine 2,3-aminomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.6 5.4.3.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJS OCA]. 

==Reference==
Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM., Montavon TJ, Christianson CV, Festin GM, Shen B, Bruner SD, Bioorg Med Chem Lett. 2007 Nov 19;. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18078753 18078753]
[[Category: Single protein]]
[[Category: Streptomyces globisporus]]
[[Category: Tyrosine 2,3-aminomutase]]
[[Category: Bruner, S.D.]]
[[Category: Christianson, C.V.]]
[[Category: Montavon, T.J.]]
[[Category: 296]]
[[Category: 4-methylidene imidazole]]
[[Category: aminomutase]]
[[Category: c-1027]]
[[Category: isomerase]]
[[Category: mio]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 11:09:31 2008''