View source for 1dzk

[[Image:1dzk.gif|left|200px]]<br />
<applet load="1dzk" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1dzk, resolution 1.48&Aring;" />
'''PORCINE ODORANT BINDING PROTEIN COMPLEXED WITH PYRAZINE (2-ISOBUTYL-3-METOXYPYRAZINE)'''<br />

==Overview==
Porcine odorant binding protein (pOBP) is a monomer of 157 amino acid, residues, purified in abundance from pig nasal mucosa. In contrast to the, observation on lipocalins as retinol binding protein (RBP), major urinary, protein (MUP) or bovine odorant binding protein (bOBP), no naturally, occurring ligand was found in the beta-barrel cavity of pOBP. Porcine OBP, was therefore chosen as a simple model for structure/function studies with, odorant molecules. In competition experiments with tritiated pyrazine, the, affinity of pOBP towards several odorant molecules belonging to different, chemical classes has been found to be of the micromolar order, with a 1:1, stoichiometry. The X-ray structures of pOBP complexed to these molecules, were determined at resolution between 2.15 and 1.4 A. As ... [[http://ispc.weizmann.ac.il/pmbin/getpm?10864504 (full description)]]

==About this Structure==
1DZK is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]] with PRZ as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Sites: AC1 and AC2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DZK OCA]]. 

==Reference==
Complexes of porcine odorant binding protein with odorant molecules belonging to different chemical classes., Vincent F, Spinelli S, Ramoni R, Grolli S, Pelosi P, Cambillau C, Tegoni M, J Mol Biol. 2000 Jun 30;300(1):127-39. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10864504 10864504]
[[Category: Single protein]]
[[Category: Sus scrofa]]
[[Category: Cambillau, C.]]
[[Category: Spinelli, S.]]
[[Category: Tegoni, M.]]
[[Category: Vincent, F.]]
[[Category: PRZ]]
[[Category: lipocalins]]
[[Category: odorant binding protein]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:01:26 2007''