View source for 2bxc

[[Image:2bxc.gif|left|200px]]<br /><applet load="2bxc" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="2bxc, resolution 3.10&Aring;" />
'''HUMAN SERUM ALBUMIN COMPLEXED WITH PHENYLBUTAZONE'''<br />

==Overview==
Human serum albumin (HSA) is an abundant plasma protein that binds a, remarkably wide range of drugs, thereby restricting their free, active, concentrations. The problem of overcoming the binding affinity of lead, compounds for HSA represents a major challenge in drug development., Crystallographic analysis of 17 different complexes of HSA with a wide, variety of drugs and small-molecule toxins reveals the precise, architecture of the two primary drug-binding sites on the protein, identifying residues that are key determinants of binding specificity and, illuminating the capacity of both pockets for flexible accommodation., Numerous secondary binding sites for drugs distributed across the protein, have also been identified. The binding of fatty acids, the primary, physiological ligand for the protein, is shown to alter the polarity and, increase the volume of drug site 1. These results clarify the, interpretation of accumulated drug binding data and provide a valuable, template for design efforts to modulate the interaction with HSA.

==Disease==
Known diseases associated with this structure: Analbuminemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=103600 103600]], Dysalbuminemic hyperthyroxinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=103600 103600]], Dysalbuminemic hyperzincemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=103600 103600]]

==About this Structure==
2BXC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with P1Z as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:P1z Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BXC OCA]. 

==Reference==
Structural basis of the drug-binding specificity of human serum albumin., Ghuman J, Zunszain PA, Petitpas I, Bhattacharya AA, Otagiri M, Curry S, J Mol Biol. 2005 Oct 14;353(1):38-52. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16169013 16169013]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Bhattacharya, A.A.]]
[[Category: Curry, S.]]
[[Category: Ghuman, J.]]
[[Category: Petitpas, I.]]
[[Category: Zunszain, P.A.]]
[[Category: P1Z]]
[[Category: albumin]]
[[Category: carrier protein]]
[[Category: drug-binding]]
[[Category: lipid-binding]]
[[Category: metal-binding]]
[[Category: phenylbutazone]]
[[Category: transport protein]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 19:01:50 2007''