View source for 1oiq

[[Image:1oiq.gif|left|200px]]<br /><applet load="1oiq" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1oiq, resolution 2.31&Aring;" />
'''IMIDAZOPYRIDINES: A POTENT AND SELECTIVE CLASS OF CYCLIN-DEPENDENT KINASE INHIBITORS IDENTIFIED THROUGH STRUCTURE-BASED HYBRIDISATION'''<br />

==Overview==
High-throughput screening identified the imidazo[1,2-a]pyridine and, bisanilinopyrimidine series as inhibitors of the cyclin-dependent kinase, CDK4. Comparison of their experimentally-determined binding modes and, emerging structure-activity trends led to the development of potent and, selective imidazo[1,2-a]pyridine inhibitors for CDK4 and in particular, CDK2.

==About this Structure==
1OIQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with HDU as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Transferred_entry:_2.7.11.1 Transferred entry: 2.7.11.1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.37 2.7.1.37] Known structural/functional Site: <scene name='pdbsite=AC1:Hdu Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OIQ OCA]. 

==Reference==
Imidazo[1,2-a]pyridines: a potent and selective class of cyclin-dependent kinase inhibitors identified through structure-based hybridisation., Anderson M, Beattie JF, Breault GA, Breed J, Byth KF, Culshaw JD, Ellston RP, Green S, Minshull CA, Norman RA, Pauptit RA, Stanway J, Thomas AP, Jewsbury PJ, Bioorg Med Chem Lett. 2003 Sep 15;13(18):3021-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12941325 12941325]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Transferred entry: 2.7.11.1]]
[[Category: Beattie, J.F.]]
[[Category: Breault, G.A.]]
[[Category: Byth, K.F.]]
[[Category: Culshaw, J.D.]]
[[Category: Ellston, R.P.A.]]
[[Category: Green, S.]]
[[Category: Jewsbury, P.J.]]
[[Category: Minshull, C.A.]]
[[Category: Norman, R.A.]]
[[Category: Pauptit, R.A.]]
[[Category: Thomas, A.P.]]
[[Category: HDU]]
[[Category: atp-binding]]
[[Category: cell cycle]]
[[Category: cell division]]
[[Category: mitosis]]
[[Category: phosphorylation]]
[[Category: protein kinase]]
[[Category: serine/threonine-protein kinase]]
[[Category: transferase]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 17:45:50 2007''