View source for 1cwk

[[Image:1cwk.gif|left|200px]]<br />
<applet load="1cwk" size="450" color="white" frame="true" align="right" spinBox="true" 
caption="1cwk, resolution 1.80&Aring;" />
'''HUMAN CYCLOPHILIN A COMPLEXED WITH 1-(6,7-DIHYDRO)MEBMT 2-VAL 3-D-(2-S-METHYL)SARCOSINE CYCLOSPORIN'''<br />

==Overview==
Eight new X-ray structures of different cyclophilin, A/cyclosporin-derivative complexes are presented. These structures, combined with the existing three published cyclosporin complexes, provide, a useful structural database for the analysis of protein-ligand, interactions. The effect of small chemical differences on protein-ligand, hydrogen-bonding, van der Waals interactions and water structure is, presented.

==About this Structure==
1CWK is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8]]. Structure known Active Site: BIN. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CWK OCA]]. 

==Reference==
X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A., Kallen J, Mikol V, Taylor P, Walkinshaw MD, J Mol Biol. 1998 Oct 23;283(2):435-49. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9769216 9769216]
[[Category: Homo sapiens]]
[[Category: Peptidylprolyl isomerase]]
[[Category: Single protein]]
[[Category: Kallen, J.]]
[[Category: Mikol, V.]]
[[Category: Taylor, P.]]
[[Category: Walkinshaw, M.D.]]
[[Category: complex (isomerase/immunosuppressant)]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:26:54 2007''