View source for 8ep1


==Eag Kv channel with voltage sensor in the down conformation==
<StructureSection load='8ep1' size='340' side='right'caption='[[8ep1]], [[Resolution|resolution]] 5.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ep1]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EP1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ep1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ep1 OCA], [https://pdbe.org/8ep1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ep1 RCSB], [https://www.ebi.ac.uk/pdbsum/8ep1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ep1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KCNH1_RAT KCNH1_RAT] Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel. Channel properties may be modulated by subunit assembly, but not by cyclic nucleotides (By similarity). Mediates IK(NI) current in myoblasts (By similarity). Involved in the regulation of cell proliferation and differentiation, as adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (By similarity).[UniProtKB:O95259][UniProtKB:Q60603]

==See Also==
*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: MacKinnon R]]
[[Category: Mandala VS]]