View source for 7stx


==Cryo-EM structure of human NatB in complex with CoA-Alpha-Synuclein==
<StructureSection load='7stx' size='340' side='right'caption='[[7stx]], [[Resolution|resolution]] 3.14&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7stx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7STX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7STX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.14&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7stx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7stx OCA], [https://pdbe.org/7stx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7stx RCSB], [https://www.ebi.ac.uk/pdbsum/7stx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7stx ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/NAA20_HUMAN NAA20_HUMAN] Autosomal recessive non-syndromic intellectual disability. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/NAA20_HUMAN NAA20_HUMAN] Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln (PubMed:34230638). Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.<ref>PMID:18570629</ref> <ref>PMID:34230638</ref> 

==See Also==
*[[Alpha-synuclein|Alpha-synuclein]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Deng S]]
[[Category: Marmorstein R]]