View source for 7sr4


==Single chain trimer HLA-A*02:01 (H98L, Y108C) with HPV.16 E7 peptide YMLDLQPETTDLYC==
<StructureSection load='7sr4' size='340' side='right'caption='[[7sr4]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7sr4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Pongo_pygmaeus Pongo pygmaeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SR4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sr4 OCA], [https://pdbe.org/7sr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sr4 RCSB], [https://www.ebi.ac.uk/pdbsum/7sr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sr4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VE7_HPV16 VE7_HPV16] Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).[HAMAP-Rule:MF_04004]<ref>PMID:11080488</ref> <ref>PMID:1316611</ref> <ref>PMID:2836062</ref> [https://www.uniprot.org/uniprot/A0A678ZGP6_HUMAN A0A678ZGP6_HUMAN] [https://www.uniprot.org/uniprot/B2MG_PONPY B2MG_PONPY] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Human papillomavirus type 16]]
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Pongo pygmaeus]]
[[Category: Finton KAK]]
[[Category: Rupert PB]]