View source for 7ptf


==Pseudomonas aeruginosa DNA gyrase B 24kDa ATPase subdomain complexed with novobiocin==
<StructureSection load='7ptf' size='340' side='right'caption='[[7ptf]], [[Resolution|resolution]] 1.32&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7ptf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PTF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PTF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.32&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NOV:NOVOBIOCIN'>NOV</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ptf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ptf OCA], [https://pdbe.org/7ptf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ptf RCSB], [https://www.ebi.ac.uk/pdbsum/7ptf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ptf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GYRB_PSEAE GYRB_PSEAE] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

==See Also==
*[[Gyrase 3D Structures|Gyrase 3D Structures]]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Burton N]]
[[Category: Cotman AE]]
[[Category: Ilas J]]
[[Category: Kikelj D]]
[[Category: Lawson DM]]
[[Category: Masic LP]]
[[Category: Maxwell A]]
[[Category: Mundy JEA]]
[[Category: Stevenson CEM]]
[[Category: Tomasic T]]
[[Category: Zega A]]
[[Category: Zidar N]]