View source for 7ko6


==C1B domain of Protein kinase C in complex with ingenol-3-angelate and phosphocholine==
<StructureSection load='7ko6' size='340' side='right'caption='[[7ko6]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7ko6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KO6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WUD:ingenol-3-angelate'>WUD</scene>, <scene name='pdbligand=XP5:(4S,7R)-7-(HEPTANOYLOXY)-4-HYDROXY-N,N,N-TRIMETHYL-10-OXO-3,5,9-TRIOXA-4-PHOSPHAHEXADECAN-1-AMINIUM+4-OXIDE'>XP5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ko6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ko6 OCA], [https://pdbe.org/7ko6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ko6 RCSB], [https://www.ebi.ac.uk/pdbsum/7ko6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ko6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A140UHX0_RAT A0A140UHX0_RAT] Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.[PIRNR:PIRNR000551]

==See Also==
*[[Protein kinase C 3D structures|Protein kinase C 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Katti SS]]
[[Category: Krieger IV]]