View source for 7el5


==Crystal structure of Sizzled protein from Xenopus Laevis==
<StructureSection load='7el5' size='340' side='right'caption='[[7el5]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7el5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EL5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EL5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7el5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7el5 OCA], [https://pdbe.org/7el5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7el5 RCSB], [https://www.ebi.ac.uk/pdbsum/7el5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7el5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A8J1MPX0_XENLA A0A8J1MPX0_XENLA] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Sizzled (Szl) is both a secreted frizzled related protein (sFRP) and a naturally occurring inhibitor of the zinc metalloproteinase bone morphogenetic protein-1 (BMP-1), a key regulator of extracellular matrix assembly and growth factor activation. Here we present a new crystal structure for Szl which differs from that previously reported by a large scale (90 degrees ) hinge rotation between its cysteine-rich and netrin-like domains. We also present results of a molecular docking analysis showing interactions likely to be involved in the inhibition of BMP-1 activity by Szl. When compared with known structures of BMP-1 in complex with small molecule inhibitors, this reveals features that may be helpful in the design of new inhibitors to prevent the excessive accumulation of extracellular matrix that is the hallmark of fibrotic diseases.

Dynamics of the secreted frizzled related protein Sizzled and potential implications for binding to bone morphogenetic protein-1 (BMP-1).,Sharma U, Vadon-Le Goff S, Harlos K, Zhao Y, Mariano N, Bijakowski C, Bourhis JM, Moali C, Hulmes DJS, Aghajari N Sci Rep. 2022 Sep 1;12(1):14850. doi: 10.1038/s41598-022-18795-4. PMID:36050373<ref>PMID:36050373</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7el5" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Xenopus laevis]]
[[Category: Aghajari N]]
[[Category: Harlos K]]
[[Category: Hulmes DJS]]
[[Category: Sharma U]]