View source for 6mzc


==Human TFIID BC core==
<SX load='6mzc' size='340' side='right' viewer='molstar' caption='[[6mzc]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6mzc]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MZC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mzc OCA], [https://pdbe.org/6mzc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mzc RCSB], [https://www.ebi.ac.uk/pdbsum/6mzc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mzc ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TAF2_HUMAN TAF2_HUMAN] Microcephaly-thin corpus callosum-intellectual disability syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/TAF2_HUMAN TAF2_HUMAN] Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter.<ref>PMID:9418870</ref> <ref>PMID:9774672</ref> 

==See Also==
*[[Transcription initiation factors 3D structures|Transcription initiation factors 3D structures]]
== References ==
<references/>
__TOC__
</SX>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Fang J]]
[[Category: Greber BJ]]
[[Category: Grunberg S]]
[[Category: Hahn S]]
[[Category: Liu Y]]
[[Category: Louder RK]]
[[Category: Luo J]]
[[Category: Nogales E]]
[[Category: Patel AB]]
[[Category: Ranish J]]