View source for 6iew


==The crystal structure of the dNxf2 UBA domain in complex with Panoramix==
<StructureSection load='6iew' size='340' side='right'caption='[[6iew]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6iew]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IEW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IEW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iew OCA], [https://pdbe.org/6iew PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iew RCSB], [https://www.ebi.ac.uk/pdbsum/6iew PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iew ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NXF2_DROME NXF2_DROME] May be involved in the export of mRNA from the nucleus to the cytoplasm.<ref>PMID:11780633</ref> [https://www.uniprot.org/uniprot/PANX_DROME PANX_DROME] Acts via the piwi-interacting RNA (piRNA) pathway which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:26472911, PubMed:26494711). Required for transcriptional silencing of transposons targeted by piwi and confers its effects by interacting with nascent RNA transcripts (PubMed:26472911, PubMed:26494711). Likely to be recruited to nascent transcripts cotranscriptionally by piwi and to recruit additional factors involved in transcriptional silencing (PubMed:26472911). In the ovaries, forms a complex with nxf2, piwi and Nxt1 which acts as effectors of cotranscriptional transposon silencing (PubMed:31219034, PubMed:31368590, PubMed:31570835, PubMed:31384064). The interaction with nxf2 stabilizes the nuclear protein complex (PubMed:31384064).<ref>PMID:26472911</ref> <ref>PMID:26494711</ref> <ref>PMID:31219034</ref> <ref>PMID:31368590</ref> <ref>PMID:31384064</ref> <ref>PMID:31570835</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Cheng S]]
[[Category: Huang Y]]