View source for 5tpg


==Optimization of spirocyclic proline tryptophanhydroxylase-1 inhibitors==
<StructureSection load='5tpg' size='340' side='right'caption='[[5tpg]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5tpg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TPG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7H5:(3S)-8-(2-AMINO-6-{(1R)-1-[5-CHLORO-3-(METHYLSULFONYL)[1,1-BIPHENYL]-2-YL]-2,2,2-TRIFLUOROETHOXY}PYRIMIDIN-4-YL)-2,8-DIAZASPIRO[4.5]DECANE-3-CARBOXYLIC+ACID'>7H5</scene>, <scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tpg OCA], [https://pdbe.org/5tpg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tpg RCSB], [https://www.ebi.ac.uk/pdbsum/5tpg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tpg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TPH1_HUMAN TPH1_HUMAN] 

==See Also==
*[[Hydroxylases 3D structures|Hydroxylases 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: De Lombaert S]]
[[Category: Goldberg DR]]
[[Category: Holt MC]]
[[Category: Stein AJ]]