View source for 5md2


==The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=5, twist=-6==
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== Structural highlights ==
<table><tr><td colspan='2'>[[5md2]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MD2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5md2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5md2 OCA], [https://pdbe.org/5md2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5md2 RCSB], [https://www.ebi.ac.uk/pdbsum/5md2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5md2 ProSAT]</span></td></tr>
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== Function ==
[https://www.uniprot.org/uniprot/Q72497_9HIV1 Q72497_9HIV1] Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).  Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity).[SAAS:SAAS012344_004_011858]
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== Publication Abstract from PubMed ==
HIV-1 contains a cone-shaped capsid encasing the viral genome. This capsid is thought to follow fullerene geometry-a curved hexameric lattice of the capsid protein, CA, closed by incorporating 12 CA pentamers. Current models for core structure are based on crystallography of hexameric and cross-linked pentameric CA, electron microscopy of tubular CA arrays, and simulations. Here, we report subnanometer-resolution cryo-electron tomography structures of hexameric and pentameric CA within intact HIV-1 particles. Whereas the hexamer structure is compatible with crystallography studies, the pentamer forms using different interfaces. Determining multiple structures revealed how CA flexes to form the variably curved core shell. We show that HIV-1 CA assembles both aberrant and perfect fullerene cones, supporting models in which conical cores assemble de novo after maturation.

The structure and flexibility of conical HIV-1 capsids determined within intact virions.,Mattei S, Glass B, Hagen WJ, Krausslich HG, Briggs JA Science. 2016 Dec 16;354(6318):1434-1437. PMID:27980210<ref>PMID:27980210</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==See Also==
*[[Gag polyprotein 3D structures|Gag polyprotein 3D structures]]
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
<references/>
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[[Category: Human immunodeficiency virus 1]]
[[Category: Large Structures]]
[[Category: Briggs JAG]]
[[Category: Glass B]]
[[Category: Hagen WJH]]
[[Category: Kraeusslich H-G]]
[[Category: Mattei S]]